Laboratory of Molecular Biophysics Graduate Student Opportunities.

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Structural studies on eukaryotic cell cycle control proteins

• Structural consequences of CDK phosphorylation.
• Interactions between CDKs and their regulatory molecules.
• Molecular complexes responsible for targeted degradation of CDK regulatory proteins.
• Design of small molecule CDK inhibitors as potential anticancer agents.

Selected references.

Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell. 2005 Oct 28;20(2):199-211.

Trempe JF, Brown NR, Lowe ED, Gordon C, Campbell ID, Noble ME, Endicott JA. Mechanism of Lys48-linked polyubiquitin chain recognition by the Mud1 UBA domain. EMBO J. 2005 Sep 21;24(18):3178-89.

Welburn JP, Endicott JA. Inhibition of the cell cycle with chemical inhibitors: a targeted approach. Semin Cell Dev Biol. 2005 Jun;16(3):369-81. Review.

Davies TG, Bentley J, Arris CE, Boyle FT, Curtin NJ, Endicott JA, Gibson AE, Golding BT, Griffin RJ, Hardcastle IR, Jewsbury P, Johnson LN, Mesguiche V, Newell DR, Noble ME, Tucker JA, Wang L, Whitfield HJ. Structure-based design of a potent purine-based cyclin-dependent kinase inhibitor. Nat Struct Biol. 2002 Oct;9(10):745-9.