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Control of cellular processes by phosphorylation and ubiquitination

• cell cycle proteins and protein kinases
• structural basis of cellular control processes

Selected references.

Cheng, K-Y, Lowe, E. D., Sinclair, J., Nigg, E. A. and Johnson, L. N. (2003) The crystal structure of human polo-like kinase-1 polo box domain and its phospho-peptide complex. EMBO J.22, 5757-5768.

Noble, M. E. M., Endicott, J. A. & Johnson, L. N. (2004) Protein kinase inhibitors. Science 303,1713-1928.

Lolli, G., Lowe, E. D., Brown, N. R. and Johnson, L. N. (2004) The crystal structure of human CDK7 and its protein recognition properties. Structure 12, 2067-2079.

Honda, R., Lowe, E.D., Dubinina, E., Skamnaki, V., Cook, A., Brown, N. R. and Johnson, L. N. (2005) The structure of cyclin E1 in complex with CDK2; implications for CDK2 activation and CDK2 independent roles. EMBO J. 24, 452-463.

Brown, N. R., Noble, M. E. M., Endicott, J. A. & Johnson, L. N. (1999). The structural basis for specificity of substrate and recruitment peptides for cyclin- dependent kinases. Nature Cell Biology 1, 438-443.

Song, H., Hanlan, N., Brown, N.R., Noble, M. E. M., Johnson, L. N. & Barford, D. (2001). Phospho-protein/protein interactions: the crystal structure of Kinase Associated Phosphatase (KAP) in complex with CDK2. Molecular Cell 7, 615-626.