Oxford University

Laboratory of Molecular Biophysics
Graduate Student Opportunities.

Graduate Student Opportunities.

Dr. Susan Lea

contact details

Structural studies on pathogenesis


Selected references.

Cordes FS, Daniell S, Kenjale R, Saurya S, Picking WL, Picking WD, Booy F, Lea SM, Blocker A. Helical Packing of Needles from Functionally Altered Shigella Type III Secretion Systems. J Mol Biol. 2005 Oct 7;

Dey AK, Khati M, Tang M, Wyatt R, Lea SM, James W., An aptamer that neutralizes R5 strains of human immunodeficiency virus type 1 blocks gp120-CCR5 interaction. J Virol. 2005 Nov;79(21):13806-10.

Cordes FS, Roversi P, Kraiczy P, Simon MM, Brade V, Jahraus O, Wallis R, Skerka C, Zipfel PF, Wallich R, Lea SM. A novel fold for the factor H-binding protein BbCRASP-1 of Borrelia burgdorferi. Nat Struct Mol Biol. 2005 Mar;12(3):276-7.

Harris CL, Abbott RJ, Smith RA, Morgan BP, Lea SM., Molecular dissection of interactions between components of the alternative pathway of complement and decay accelerating factor (CD55). J Biol Chem. 2005 Jan 28;280(4):2569-78.

Pettigrew D, Anderson KL, Billington J, Cota E, Simpson P, Urvil P, Rabuzin F, Roversi P, Nowicki B, du Merle L, Le Bouguenec C, Matthews S, Lea SM. High resolution studies of the Afa/Dr adhesin DraE and its interaction with chloramphenicol. J Biol Chem. 2004 Nov 5;279(45):46851-7. Epub 2004 Aug 24.

Anderson KL, Billington J, Pettigrew D, Cota E, Simpson P, Roversi P, Chen HA, Urvil P, du Merle L, Barlow PN, Medof ME, Smith RA, Nowicki B, Le Bouguenec C, Lea SM, Matthews S. An atomic resolution model for assembly, architecture, and function of the Dr adhesins. Mol Cell. 2004 Aug 27;15(4):647-57.

Lukacik P, Roversi P, White J, Esser D, Smith GP, Billington J, Williams PA, Rudd PM, Wormald MR, Harvey DJ, Crispin MD, Radcliffe CM, Dwek RA, Evans DJ, Morgan BP, Smith RA, Lea SM. Complement regulation at the molecular level: the structure of decay-accelerating factor. Proc Natl Acad Sci U S A. 2004 Feb 3;101(5):1279-84.

Bhella D, Goodfellow IG, Roversi P, Pettigrew D, Chaudhry Y, Evans DJ, Lea SM. The structure of echovirus type 12 bound to a two-domain fragment of its cellular attachment protein decay-accelerating factor (CD 55). J Biol Chem. 2004 Feb 27;279(9):8325-32.

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Last updated: 28-Oct-2005