Graduate Student Opportunities.

Laboratory of Molecular Biophysics
Graduate Student Opportunities.

Graduate Student Opportunities.

Prof. Martin E.M. Noble

contact details

Structure-function relationships of medically important proteins

transient protein-protein association and control by reversible phosphorylation
visualisation and analysis of protein structures for structure based drug design

Selected references.

Macdonald N, Welburn JP, Noble ME, Nguyen A, Yaffe MB, Clynes D, Moggs JG, Orphanides G, Thomson S, Edmunds JW, Clayton AL, Endicott JA, Mahadevan LC. Molecular basis for the recognition of phosphorylated and phosphoacetylated histone h3 by 14-3-3. Mol Cell. 2005 Oct 28;20(2):199-211.

Sandy J, Mushtaq A, Holton SJ, Schartau P, Noble ME, Sim E. Investigation of the catalytic triad of arylamine N-acetyltransferases: essential residues required for acetyl transfer to arylamines. Biochem J. 2005 Aug 15;390(Pt 1):115-23.

Barrett CP, Noble ME. Molecular motions of human cyclin-dependent kinase 2. J Biol Chem. 2005 Apr 8;280(14):13993-4005.

Pratt DJ, Endicott JA, Noble ME. The role of structure in kinase-targeted inhibitor design. Curr Opin Drug Discov Devel. 2004 Jul;7(4):428-36. Review.

Noble ME, Endicott JA, Johnson LN. Protein kinase inhibitors: insights into drug design from structure. Science. 2004 Mar 19;303(5665):1800-5. Review.

Hoellerer MK, Noble ME, Labesse G, Campbell ID, Werner JM, Arold ST. Molecular recognition of paxillin LD motifs by the focal adhesion targeting domain. Structure (Camb). 2003 Oct;11(10):1207-17.

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Last updated: 28-Oct-2005

Laboratory of Molecular Biophysics Graduate Student Opportunities.